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Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Identifieur interne : 004686 ( Main/Exploration ); précédent : 004685; suivant : 004687

Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus

Auteurs : Yi Lu [Australie] ; Veronique Vitart [Royaume-Uni] ; Kathryn P. Burdon [Australie] ; Chiea Chuen Khor [Singapour] ; Yelena Bykhovskaya [États-Unis] ; Alireza Mirshahi [Allemagne] ; Alex W. Hewitt [Australie] ; Demelza Koehn [États-Unis] ; Pirro G. Hysi [Royaume-Uni] ; Wishal D. Ramdas [Pays-Bas] ; Tanja Zeller [Allemagne] ; Eranga N. Vithana [Singapour] ; Belinda K. Cornes [Singapour] ; Wan-Ting Tay [Singapour] ; E Shyong Tai [Singapour] ; Ching-Yu Cheng [Singapour] ; Jianjun Liu [Singapour] ; Jia-Nee Foo [Singapour] ; Seang Mei Saw [Singapour] ; Gudmar Thorleifsson [Islande] ; Kari Stefansson [Islande] ; David P. Dimasi [Australie] ; Richard A. Mills [Australie] ; Jenny Mountain [Australie] ; Wei Ang [Australie] ; René Hoehn [Allemagne] ; Virginie J M. Verhoeven [Pays-Bas] ; Franz Grus [Allemagne] ; Roger Wolfs [Pays-Bas] ; Raphaële Castagne [France] ; Karl J. Lackner [Allemagne] ; Henriët Springelkamp [Pays-Bas] ; Jian Yang [Australie] ; Fridbert Jonasson [Islande] ; Dexter Y L. Leung [Hong Kong] ; Li J. Chen [Hong Kong] ; Clement C Y. Tham [Hong Kong] ; Igor Rudan [Royaume-Uni, Croatie] ; Zoran Vatavuk [Croatie] ; Caroline Hayward [Royaume-Uni] ; Jane Gibson [Royaume-Uni] ; Angela J. Cree [Royaume-Uni] ; Alex Macleod [Royaume-Uni] ; Sarah Ennis [Royaume-Uni] ; Ozren Polasek [Croatie] ; Harry Campbell [Royaume-Uni] ; James F. Wilson [Royaume-Uni] ; Ananth C. Viswanathan [Royaume-Uni] ; Brian Fleck [Royaume-Uni] ; Xiaohui Li [États-Unis] ; David Siscovick [États-Unis] ; Kent D. Taylor [États-Unis] ; Jerome I. Rotter [États-Unis] ; Seyhan Yazar [Australie] ; Megan Ulmer [États-Unis] ; Jun Li [États-Unis] ; Brian L. Yaspan [États-Unis] ; Ayse B. Ozel [États-Unis] ; Julia E. Richards [États-Unis] ; Sayoko E. Moroi [États-Unis] ; Jonathan L. Haines [États-Unis] ; Jae H. Kang [États-Unis] ; Louis R. Pasquale [États-Unis] ; R Rand Allingham [États-Unis] ; Allison Ashley-Koch [États-Unis] ; Paul Mitchell [Australie] ; Jie Jin Wang [Australie] ; Alan F. Wright [Royaume-Uni] ; Craig Pennell [Australie] ; Timothy D. Spector [Royaume-Uni] ; Terri L. Young [États-Unis, Singapour] ; Caroline C W. Klaver [Pays-Bas] ; Nicholas G. Martin [Australie] ; Grant W. Montgomery [Australie] ; Michael G. Anderson [États-Unis] ; Tin Aung [Singapour] ; Colin E. Willoughby [Royaume-Uni] ; Janey L. Wiggs [États-Unis] ; Chi P. Pang [Hong Kong] ; Unnur Thorsteinsdottir [Islande] ; Andrew J. Lotery [Royaume-Uni] ; Christopher J. Hammond [Royaume-Uni] ; Cornelia M. Van Duijn [Pays-Bas] ; Michael A. Hauser [États-Unis] ; Yaron S. Rabinowitz [États-Unis] ; Norbert Pfeiffer [Allemagne] ; David A. Mackey [Australie] ; Jamie E. Craig [Australie] ; Stuart Macgregor [Australie] ; Tien Y. Wong [Singapour, États-Unis]

Source :

RBID : PMC:3720123

Abstract

Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (P < 5 × 10−8). We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4–1.88, P = 2.7 × 10−10, and rs4894535 in FNDC3B had OR = 1.47, 95% CI = 1.29–1.68, P = 4.9 × 10−9). FNDC3B was also associated with primary open-angle glaucoma (P = 5.6 × 10−4; tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.


Url:
DOI: 10.1038/ng.2506
PubMed: 23291589
PubMed Central: 3720123


Affiliations:

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Le document en format XML

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<name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name>
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<name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
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<name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name>
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<nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
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<name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name>
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<nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
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<name sortKey="Dimasi, David P" sort="Dimasi, David P" uniqKey="Dimasi D" first="David P" last="Dimasi">David P. Dimasi</name>
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<name sortKey="Mills, Richard A" sort="Mills, Richard A" uniqKey="Mills R" first="Richard A" last="Mills">Richard A. Mills</name>
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<name sortKey="Mountain, Jenny" sort="Mountain, Jenny" uniqKey="Mountain J" first="Jenny" last="Mountain">Jenny Mountain</name>
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<author>
<name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name>
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<nlm:aff id="A22">School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
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<name sortKey="Hoehn, Rene" sort="Hoehn, Rene" uniqKey="Hoehn R" first="René" last="Hoehn">René Hoehn</name>
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<nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
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</author>
<author>
<name sortKey="Verhoeven, Virginie J M" sort="Verhoeven, Virginie J M" uniqKey="Verhoeven V" first="Virginie J M" last="Verhoeven">Virginie J M. Verhoeven</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grus, Franz" sort="Grus, Franz" uniqKey="Grus F" first="Franz" last="Grus">Franz Grus</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wolfs, Roger" sort="Wolfs, Roger" uniqKey="Wolfs R" first="Roger" last="Wolfs">Roger Wolfs</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Castagne, Raphaele" sort="Castagne, Raphaele" uniqKey="Castagne R" first="Raphaële" last="Castagne">Raphaële Castagne</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Springelkamp, Henriet" sort="Springelkamp, Henriet" uniqKey="Springelkamp H" first="Henriët" last="Springelkamp">Henriët Springelkamp</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A26">Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Leung, Dexter Y L" sort="Leung, Dexter Y L" uniqKey="Leung D" first="Dexter Y L" last="Leung">Dexter Y L. Leung</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chen, Li J" sort="Chen, Li J" uniqKey="Chen L" first="Li J" last="Chen">Li J. Chen</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tham, Clement C Y" sort="Tham, Clement C Y" uniqKey="Tham C" first="Clement C Y" last="Tham">Clement C Y. Tham</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Vatavuk, Zoran" sort="Vatavuk, Zoran" uniqKey="Vatavuk Z" first="Zoran" last="Vatavuk">Zoran Vatavuk</name>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb</wicri:regionArea>
<wicri:noRegion>Zagreb</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation wicri:level="4">
<nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Gibson, Jane" sort="Gibson, Jane" uniqKey="Gibson J" first="Jane" last="Gibson">Jane Gibson</name>
<affiliation wicri:level="1">
<nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cree, Angela J" sort="Cree, Angela J" uniqKey="Cree A" first="Angela J" last="Cree">Angela J. Cree</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Macleod, Alex" sort="Macleod, Alex" uniqKey="Macleod A" first="Alex" last="Macleod">Alex Macleod</name>
<affiliation wicri:level="1">
<nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name>
<affiliation wicri:level="1">
<nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A34">Department of Public Health, University of Split, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Viswanathan, Ananth C" sort="Viswanathan, Ananth C" uniqKey="Viswanathan A" first="Ananth C" last="Viswanathan">Ananth C. Viswanathan</name>
<affiliation wicri:level="3">
<nlm:aff id="A35">National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fleck, Brian" sort="Fleck, Brian" uniqKey="Fleck B" first="Brian" last="Fleck">Brian Fleck</name>
<affiliation wicri:level="3">
<nlm:aff id="A36">Princess Alexandra Eye Pavilion, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Siscovick, David" sort="Siscovick, David" uniqKey="Siscovick D" first="David" last="Siscovick">David Siscovick</name>
<affiliation wicri:level="4">
<nlm:aff id="A38">Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ulmer, Megan" sort="Ulmer, Megan" uniqKey="Ulmer M" first="Megan" last="Ulmer">Megan Ulmer</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<affiliation wicri:level="2">
<nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yaspan, Brian L" sort="Yaspan, Brian L" uniqKey="Yaspan B" first="Brian L" last="Yaspan">Brian L. Yaspan</name>
<affiliation wicri:level="2">
<nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name>
<affiliation wicri:level="2">
<nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name>
<affiliation wicri:level="2">
<nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name>
<affiliation wicri:level="2">
<nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="2">
<nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name>
<affiliation wicri:level="2">
<nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
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<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name>
<affiliation wicri:level="2">
<nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name>
<affiliation wicri:level="2">
<nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ashley Koch, Allison" sort="Ashley Koch, Allison" uniqKey="Ashley Koch A" first="Allison" last="Ashley-Koch">Allison Ashley-Koch</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="4">
<nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
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<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="4">
<nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name>
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<nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
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</author>
<author>
<name sortKey="Pennell, Craig" sort="Pennell, Craig" uniqKey="Pennell C" first="Craig" last="Pennell">Craig Pennell</name>
<affiliation wicri:level="1">
<nlm:aff id="A22">School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia</wicri:regionArea>
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<author>
<name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name>
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<nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name>
<affiliation wicri:level="2">
<nlm:aff id="A47">Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Genetics, Duke University Medical Center, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48">Duke-National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Duke-National University of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C W" last="Klaver">Caroline C W. Klaver</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1">
<nlm:aff id="A49">Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Anderson, Michael G" sort="Anderson, Michael G" uniqKey="Anderson M" first="Michael G" last="Anderson">Michael G. Anderson</name>
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<nlm:aff id="A12">Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName>
<region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A51">Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName>
<region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author>
<name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A52">Singapore National Eye Centre, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore National Eye Centre</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Willoughby, Colin E" sort="Willoughby, Colin E" uniqKey="Willoughby C" first="Colin E" last="Willoughby">Colin E. Willoughby</name>
<affiliation wicri:level="1">
<nlm:aff id="A53">Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name>
<affiliation wicri:level="2">
<nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pang, Chi P" sort="Pang, Chi P" uniqKey="Pang C" first="Chi P" last="Pang">Chi P. Pang</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name>
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<nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
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<affiliation wicri:level="1">
<nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name>
<affiliation wicri:level="3">
<nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
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</affiliation>
</author>
<author>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rabinowitz, Yaron S" sort="Rabinowitz, Yaron S" uniqKey="Rabinowitz Y" first="Yaron S" last="Rabinowitz">Yaron S. Rabinowitz</name>
<affiliation wicri:level="2">
<nlm:aff id="A8">Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California</wicri:regionArea>
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<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A54">Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
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<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<affiliation wicri:level="4">
<nlm:aff id="A10">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
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<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
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</author>
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<name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
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</author>
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<name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
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<nlm:aff id="A1">Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland</wicri:regionArea>
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<name sortKey="Wong, Tien Y" sort="Wong, Tien Y" uniqKey="Wong T" first="Tien Y" last="Wong">Tien Y. Wong</name>
<affiliation wicri:level="4">
<nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
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<affiliation wicri:level="2">
<nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
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<region type="state">Caroline du Nord</region>
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<title xml:lang="en" level="a" type="main">Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus</title>
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<name sortKey="Lu, Yi" sort="Lu, Yi" uniqKey="Lu Y" first="Yi" last="Lu">Yi Lu</name>
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<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
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<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Khor, Chiea Chuen" sort="Khor, Chiea Chuen" uniqKey="Khor C" first="Chiea Chuen" last="Khor">Chiea Chuen Khor</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A7">Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)</wicri:regionArea>
<wicri:noRegion>Technology and Research (A*STAR)</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bykhovskaya, Yelena" sort="Bykhovskaya, Yelena" uniqKey="Bykhovskaya Y" first="Yelena" last="Bykhovskaya">Yelena Bykhovskaya</name>
<affiliation wicri:level="2">
<nlm:aff id="A8">Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mirshahi, Alireza" sort="Mirshahi, Alireza" uniqKey="Mirshahi A" first="Alireza" last="Mirshahi">Alireza Mirshahi</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<affiliation wicri:level="4">
<nlm:aff id="A10">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Koehn, Demelza" sort="Koehn, Demelza" uniqKey="Koehn D" first="Demelza" last="Koehn">Demelza Koehn</name>
<affiliation wicri:level="4">
<nlm:aff id="A12">Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName>
<region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author>
<name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name>
<affiliation wicri:level="3">
<nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ramdas, Wishal D" sort="Ramdas, Wishal D" uniqKey="Ramdas W" first="Wishal D" last="Ramdas">Wishal D. Ramdas</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name>
<affiliation wicri:level="3">
<nlm:aff id="A16">University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Heart Center Hamburg, Clinic for General and Interventional Cardiology, Hamburg</wicri:regionArea>
<placeName>
<settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Vithana, Eranga N" sort="Vithana, Eranga N" uniqKey="Vithana E" first="Eranga N" last="Vithana">Eranga N. Vithana</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author>
<name sortKey="Cornes, Belinda K" sort="Cornes, Belinda K" uniqKey="Cornes B" first="Belinda K" last="Cornes">Belinda K. Cornes</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tay, Wan Ting" sort="Tay, Wan Ting" uniqKey="Tay W" first="Wan-Ting" last="Tay">Wan-Ting Tay</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Tai, E Shyong" sort="Tai, E Shyong" uniqKey="Tai E" first="E Shyong" last="Tai">E Shyong Tai</name>
<affiliation wicri:level="4">
<nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A17">Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author>
<name sortKey="Cheng, Ching Yu" sort="Cheng, Ching Yu" uniqKey="Cheng C" first="Ching-Yu" last="Cheng">Ching-Yu Cheng</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A18">Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of SIngapore Graduate Medical School, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Centre for Quantitative Medicine, Office of Clinical Sciences, Duke-National University of SIngapore Graduate Medical School</wicri:regionArea>
<wicri:noRegion>Duke-National University of SIngapore Graduate Medical School</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="4">
<nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A7">Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)</wicri:regionArea>
<wicri:noRegion>Technology and Research (A*STAR)</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Foo, Jia Nee" sort="Foo, Jia Nee" uniqKey="Foo J" first="Jia-Nee" last="Foo">Jia-Nee Foo</name>
<affiliation wicri:level="1">
<nlm:aff id="A7">Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Human Genetics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR)</wicri:regionArea>
<wicri:noRegion>Technology and Research (A*STAR)</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Saw, Seang Mei" sort="Saw, Seang Mei" uniqKey="Saw S" first="Seang Mei" last="Saw">Seang Mei Saw</name>
<affiliation wicri:level="4">
<nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
</author>
<author>
<name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Dimasi, David P" sort="Dimasi, David P" uniqKey="Dimasi D" first="David P" last="Dimasi">David P. Dimasi</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mills, Richard A" sort="Mills, Richard A" uniqKey="Mills R" first="Richard A" last="Mills">Richard A. Mills</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Mountain, Jenny" sort="Mountain, Jenny" uniqKey="Mountain J" first="Jenny" last="Mountain">Jenny Mountain</name>
<affiliation wicri:level="1">
<nlm:aff id="A21">Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name>
<affiliation wicri:level="1">
<nlm:aff id="A22">School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hoehn, Rene" sort="Hoehn, Rene" uniqKey="Hoehn R" first="René" last="Hoehn">René Hoehn</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Verhoeven, Virginie J M" sort="Verhoeven, Virginie J M" uniqKey="Verhoeven V" first="Virginie J M" last="Verhoeven">Virginie J M. Verhoeven</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grus, Franz" sort="Grus, Franz" uniqKey="Grus F" first="Franz" last="Grus">Franz Grus</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wolfs, Roger" sort="Wolfs, Roger" uniqKey="Wolfs R" first="Roger" last="Wolfs">Roger Wolfs</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Castagne, Raphaele" sort="Castagne, Raphaele" uniqKey="Castagne R" first="Raphaële" last="Castagne">Raphaële Castagne</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut de Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche de Santé (UMRS) 937, Pierre and Marie Curie University and Medical School, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lackner, Karl J" sort="Lackner, Karl J" uniqKey="Lackner K" first="Karl J" last="Lackner">Karl J. Lackner</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Clinical Chemistry and Laboratory Medicine, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Springelkamp, Henriet" sort="Springelkamp, Henriet" uniqKey="Springelkamp H" first="Henriët" last="Springelkamp">Henriët Springelkamp</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jonasson, Fridbert" sort="Jonasson, Fridbert" uniqKey="Jonasson F" first="Fridbert" last="Jonasson">Fridbert Jonasson</name>
<affiliation wicri:level="1">
<nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A26">Department of Ophthalmology, Landspitali National University Hospital, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Ophthalmology, Landspitali National University Hospital, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Leung, Dexter Y L" sort="Leung, Dexter Y L" uniqKey="Leung D" first="Dexter Y L" last="Leung">Dexter Y L. Leung</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chen, Li J" sort="Chen, Li J" uniqKey="Chen L" first="Li J" last="Chen">Li J. Chen</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tham, Clement C Y" sort="Tham, Clement C Y" uniqKey="Tham C" first="Clement C Y" last="Tham">Clement C Y. Tham</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Vatavuk, Zoran" sort="Vatavuk, Zoran" uniqKey="Vatavuk Z" first="Zoran" last="Vatavuk">Zoran Vatavuk</name>
<affiliation wicri:level="1">
<nlm:aff id="A30">Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Ophthalmology, Hospital Sestre Milosrdnice, Zagreb</wicri:regionArea>
<wicri:noRegion>Zagreb</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation wicri:level="4">
<nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Gibson, Jane" sort="Gibson, Jane" uniqKey="Gibson J" first="Jane" last="Gibson">Jane Gibson</name>
<affiliation wicri:level="1">
<nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cree, Angela J" sort="Cree, Angela J" uniqKey="Cree A" first="Angela J" last="Cree">Angela J. Cree</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Macleod, Alex" sort="Macleod, Alex" uniqKey="Macleod A" first="Alex" last="Macleod">Alex Macleod</name>
<affiliation wicri:level="1">
<nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name>
<affiliation wicri:level="1">
<nlm:aff id="A31">Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Genetic Epidemiology and Genomic Informatics Group, Human Genetics, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Croatian Centre for Global Health, University of Split Medical School, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Croatian Centre for Global Health, University of Split Medical School, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A34">Department of Public Health, University of Split, Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, University of Split, Split</wicri:regionArea>
<wicri:noRegion>Split</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name>
<affiliation wicri:level="4">
<nlm:aff id="A28">Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Viswanathan, Ananth C" sort="Viswanathan, Ananth C" uniqKey="Viswanathan A" first="Ananth C" last="Viswanathan">Ananth C. Viswanathan</name>
<affiliation wicri:level="3">
<nlm:aff id="A35">National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>National Institute for Health Research (NIHR) Biomedical Research Centre, Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Fleck, Brian" sort="Fleck, Brian" uniqKey="Fleck B" first="Brian" last="Fleck">Brian Fleck</name>
<affiliation wicri:level="3">
<nlm:aff id="A36">Princess Alexandra Eye Pavilion, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Princess Alexandra Eye Pavilion, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Li, Xiaohui" sort="Li, Xiaohui" uniqKey="Li X" first="Xiaohui" last="Li">Xiaohui Li</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Siscovick, David" sort="Siscovick, David" uniqKey="Siscovick D" first="David" last="Siscovick">David Siscovick</name>
<affiliation wicri:level="4">
<nlm:aff id="A38">Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName>
<region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author>
<name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rotter, Jerome I" sort="Rotter, Jerome I" uniqKey="Rotter J" first="Jerome I" last="Rotter">Jerome I. Rotter</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name>
<affiliation wicri:level="1">
<nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ulmer, Megan" sort="Ulmer, Megan" uniqKey="Ulmer M" first="Megan" last="Ulmer">Megan Ulmer</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Li, Jun" sort="Li, Jun" uniqKey="Li J" first="Jun" last="Li">Jun Li</name>
<affiliation wicri:level="2">
<nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yaspan, Brian L" sort="Yaspan, Brian L" uniqKey="Yaspan B" first="Brian L" last="Yaspan">Brian L. Yaspan</name>
<affiliation wicri:level="2">
<nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ozel, Ayse B" sort="Ozel, Ayse B" uniqKey="Ozel A" first="Ayse B" last="Ozel">Ayse B. Ozel</name>
<affiliation wicri:level="2">
<nlm:aff id="A40">Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Human Genetics, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Richards, Julia E" sort="Richards, Julia E" uniqKey="Richards J" first="Julia E" last="Richards">Julia E. Richards</name>
<affiliation wicri:level="2">
<nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Moroi, Sayoko E" sort="Moroi, Sayoko E" uniqKey="Moroi S" first="Sayoko E" last="Moroi">Sayoko E. Moroi</name>
<affiliation wicri:level="2">
<nlm:aff id="A42">Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan</wicri:regionArea>
<placeName>
<region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Haines, Jonathan L" sort="Haines, Jonathan L" uniqKey="Haines J" first="Jonathan L" last="Haines">Jonathan L. Haines</name>
<affiliation wicri:level="2">
<nlm:aff id="A41">Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University School of Medicine, Center for Human Genetics Research, Nashville, Tennessee</wicri:regionArea>
<placeName>
<region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kang, Jae H" sort="Kang, Jae H" uniqKey="Kang J" first="Jae H" last="Kang">Jae H. Kang</name>
<affiliation wicri:level="2">
<nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pasquale, Louis R" sort="Pasquale, Louis R" uniqKey="Pasquale L" first="Louis R" last="Pasquale">Louis R. Pasquale</name>
<affiliation wicri:level="2">
<nlm:aff id="A43">Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women’s Hospital, Channing Division of Network Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Allingham, R Rand" sort="Allingham, R Rand" uniqKey="Allingham R" first="R Rand" last="Allingham">R Rand Allingham</name>
<affiliation wicri:level="2">
<nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ashley Koch, Allison" sort="Ashley Koch, Allison" uniqKey="Ashley Koch A" first="Allison" last="Ashley-Koch">Allison Ashley-Koch</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="4">
<nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="4">
<nlm:aff id="A46">Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Westmead, New South Wales</wicri:regionArea>
<orgName type="university">Université de Sydney</orgName>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name>
<affiliation wicri:level="4">
<nlm:aff id="A2">Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Medical Research Council (MRC) Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
<settlement type="city">Édimbourg</settlement>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author>
<name sortKey="Pennell, Craig" sort="Pennell, Craig" uniqKey="Pennell C" first="Craig" last="Pennell">Craig Pennell</name>
<affiliation wicri:level="1">
<nlm:aff id="A22">School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>School of Women’s and Infants’ Health, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name>
<affiliation wicri:level="3">
<nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Young, Terri L" sort="Young, Terri L" uniqKey="Young T" first="Terri L" last="Young">Terri L. Young</name>
<affiliation wicri:level="2">
<nlm:aff id="A47">Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Genetics, Duke University Medical Center, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A48">Duke-National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Duke-National University of Singapore</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Klaver, Caroline C W" sort="Klaver, Caroline C W" uniqKey="Klaver C" first="Caroline C W" last="Klaver">Caroline C W. Klaver</name>
<affiliation wicri:level="3">
<nlm:aff id="A14">Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Ophthalmology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1">
<nlm:aff id="A49">Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Genetic Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<affiliation wicri:level="1">
<nlm:aff id="A50">Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Molecular Epidemiology, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Anderson, Michael G" sort="Anderson, Michael G" uniqKey="Anderson M" first="Michael G" last="Anderson">Michael G. Anderson</name>
<affiliation wicri:level="4">
<nlm:aff id="A12">Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName>
<region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A51">Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthamology and Visual Sciences, University of Iowa, Iowa City, Iowa</wicri:regionArea>
<placeName>
<region type="state">Iowa</region>
<settlement type="city">Iowa City</settlement>
</placeName>
<orgName type="university">Université de l'Iowa</orgName>
</affiliation>
</author>
<author>
<name sortKey="Aung, Tin" sort="Aung, Tin" uniqKey="Aung T" first="Tin" last="Aung">Tin Aung</name>
<affiliation wicri:level="1">
<nlm:aff id="A4">Singapore Eye Research Institute, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore Eye Research Institute</wicri:regionArea>
</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A5">Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A52">Singapore National Eye Centre, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Singapore National Eye Centre</wicri:regionArea>
</affiliation>
</author>
<author>
<name sortKey="Willoughby, Colin E" sort="Willoughby, Colin E" uniqKey="Willoughby C" first="Colin E" last="Willoughby">Colin E. Willoughby</name>
<affiliation wicri:level="1">
<nlm:aff id="A53">Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Vision and Vascular Science, Queen’s University Belfast, Belfast</wicri:regionArea>
<wicri:noRegion>Belfast</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wiggs, Janey L" sort="Wiggs, Janey L" uniqKey="Wiggs J" first="Janey L" last="Wiggs">Janey L. Wiggs</name>
<affiliation wicri:level="2">
<nlm:aff id="A44">Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pang, Chi P" sort="Pang, Chi P" uniqKey="Pang C" first="Chi P" last="Pang">Chi P. Pang</name>
<affiliation wicri:level="4">
<nlm:aff id="A27">Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Hong Kong</nlm:aff>
<country xml:lang="fr">Hong Kong</country>
<wicri:regionArea>Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital</wicri:regionArea>
<orgName type="university">Université chinoise de Hong Kong</orgName>
<placeName>
<settlement type="city">Sha Tin</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">deCODE genetics, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A20">Faculty of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Faculty of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name>
<affiliation wicri:level="1">
<nlm:aff id="A32">Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Neurosciences Research Grouping, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A33">Southampton Eye Unit, Southampton General Hospital, Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton Eye Unit, Southampton General Hospital, Southampton</wicri:regionArea>
<wicri:noRegion>Southampton</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name>
<affiliation wicri:level="3">
<nlm:aff id="A13">Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King’s College London School of Medicine, St Thomas’ Hospital, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3">
<nlm:aff id="A15">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hauser, Michael A" sort="Hauser, Michael A" uniqKey="Hauser M" first="Michael A" last="Hauser">Michael A. Hauser</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Medicine, Duke University, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Duke University, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rabinowitz, Yaron S" sort="Rabinowitz, Yaron S" uniqKey="Rabinowitz Y" first="Yaron S" last="Rabinowitz">Yaron S. Rabinowitz</name>
<affiliation wicri:level="2">
<nlm:aff id="A8">Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Cedars-Sinai Medical Center, Division of Surgical Research, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A54">Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cornea Genetic Eye Institute, Cedars-Sinai Medical Center, Los Angeles, California</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Pfeiffer, Norbert" sort="Pfeiffer, Norbert" uniqKey="Pfeiffer N" first="Norbert" last="Pfeiffer">Norbert Pfeiffer</name>
<affiliation wicri:level="3">
<nlm:aff id="A9">Department of Ophthalmology, University Medical Center Mainz, Mainz, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Ophthalmology, University Medical Center Mainz, Mainz</wicri:regionArea>
<placeName>
<region type="land" nuts="2">Rhénanie-Palatinat</region>
<settlement type="city">Mayence</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<affiliation wicri:level="4">
<nlm:aff id="A10">Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName>
<settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A11">Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Lions Eye Institute, Centre for Ophthalmology and Visual Science, University of Western Australia, Perth, Western Australia</wicri:regionArea>
<wicri:noRegion>Western Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Ophthalmology, Flinders University, Flinders Medical Centre, Adelaide, South Australia</wicri:regionArea>
<wicri:noRegion>South Australia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
<affiliation wicri:level="1">
<nlm:aff id="A1">Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Queensland Institute of Medical Research, Statistical Genetics, Herston, Brisbane, Queensland</wicri:regionArea>
<wicri:noRegion>Queensland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wong, Tien Y" sort="Wong, Tien Y" uniqKey="Wong T" first="Tien Y" last="Wong">Tien Y. Wong</name>
<affiliation wicri:level="4">
<nlm:aff id="A6">Saw Swee Hock School of Public Health, National University of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Saw Swee Hock School of Public Health, National University of Singapore</wicri:regionArea>
<orgName type="university">Université nationale de Singapour</orgName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A45">Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint>
<date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<p id="P1">Central corneal thickness (CCT) is associated with eye conditions including keratoconus and glaucoma. We performed a meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance (
<italic>P</italic>
< 5 × 10
<sup>−8</sup>
). We further showed that 2 CCT-associated loci,
<italic>FOXO1</italic>
and
<italic>FNDC3B</italic>
, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near
<italic>FOXO1</italic>
had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4–1.88,
<italic>P</italic>
= 2.7 × 10
<sup>−10</sup>
, and rs4894535 in
<italic>FNDC3B</italic>
had OR = 1.47, 95% CI = 1.29–1.68,
<italic>P</italic>
= 4.9 × 10
<sup>−9</sup>
).
<italic>FNDC3B</italic>
was also associated with primary open-angle glaucoma (
<italic>P</italic>
= 5.6 × 10
<sup>−4</sup>
; tested in 3 cohorts with 2,979 cases and 7,399 controls). Further analyses implicate the collagen and extracellular matrix pathways in the regulation of CCT.</p>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Croatie</li>
<li>France</li>
<li>Hong Kong</li>
<li>Islande</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Singapour</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Californie</li>
<li>Caroline du Nord</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Hollande-Méridionale</li>
<li>Iowa</li>
<li>Massachusetts</li>
<li>Michigan</li>
<li>Nouvelle-Galles du Sud</li>
<li>Rhénanie-Palatinat</li>
<li>Tennessee</li>
<li>Victoria (État)</li>
<li>Washington (État)</li>
<li>Écosse</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Hambourg</li>
<li>Iowa City</li>
<li>Londres</li>
<li>Mayence</li>
<li>Melbourne</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Seattle</li>
<li>Sha Tin</li>
<li>Sydney</li>
<li>Édimbourg</li>
</settlement>
<orgName>
<li>Université chinoise de Hong Kong</li>
<li>Université d'Édimbourg</li>
<li>Université de Melbourne</li>
<li>Université de Sydney</li>
<li>Université de Washington</li>
<li>Université de l'Iowa</li>
<li>Université nationale de Singapour</li>
</orgName>
</list>
<tree>
<country name="Australie">
<noRegion>
<name sortKey="Lu, Yi" sort="Lu, Yi" uniqKey="Lu Y" first="Yi" last="Lu">Yi Lu</name>
</noRegion>
<name sortKey="Ang, Wei" sort="Ang, Wei" uniqKey="Ang W" first="Wei" last="Ang">Wei Ang</name>
<name sortKey="Burdon, Kathryn P" sort="Burdon, Kathryn P" uniqKey="Burdon K" first="Kathryn P" last="Burdon">Kathryn P. Burdon</name>
<name sortKey="Craig, Jamie E" sort="Craig, Jamie E" uniqKey="Craig J" first="Jamie E" last="Craig">Jamie E. Craig</name>
<name sortKey="Dimasi, David P" sort="Dimasi, David P" uniqKey="Dimasi D" first="David P" last="Dimasi">David P. Dimasi</name>
<name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<name sortKey="Hewitt, Alex W" sort="Hewitt, Alex W" uniqKey="Hewitt A" first="Alex W" last="Hewitt">Alex W. Hewitt</name>
<name sortKey="Macgregor, Stuart" sort="Macgregor, Stuart" uniqKey="Macgregor S" first="Stuart" last="Macgregor">Stuart Macgregor</name>
<name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<name sortKey="Mackey, David A" sort="Mackey, David A" uniqKey="Mackey D" first="David A" last="Mackey">David A. Mackey</name>
<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<name sortKey="Mills, Richard A" sort="Mills, Richard A" uniqKey="Mills R" first="Richard A" last="Mills">Richard A. Mills</name>
<name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name>
<name sortKey="Mountain, Jenny" sort="Mountain, Jenny" uniqKey="Mountain J" first="Jenny" last="Mountain">Jenny Mountain</name>
<name sortKey="Pennell, Craig" sort="Pennell, Craig" uniqKey="Pennell C" first="Craig" last="Pennell">Craig Pennell</name>
<name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<name sortKey="Yang, Jian" sort="Yang, Jian" uniqKey="Yang J" first="Jian" last="Yang">Jian Yang</name>
<name sortKey="Yazar, Seyhan" sort="Yazar, Seyhan" uniqKey="Yazar S" first="Seyhan" last="Yazar">Seyhan Yazar</name>
</country>
<country name="Royaume-Uni">
<region name="Écosse">
<name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
</region>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<name sortKey="Cree, Angela J" sort="Cree, Angela J" uniqKey="Cree A" first="Angela J" last="Cree">Angela J. Cree</name>
<name sortKey="Ennis, Sarah" sort="Ennis, Sarah" uniqKey="Ennis S" first="Sarah" last="Ennis">Sarah Ennis</name>
<name sortKey="Fleck, Brian" sort="Fleck, Brian" uniqKey="Fleck B" first="Brian" last="Fleck">Brian Fleck</name>
<name sortKey="Gibson, Jane" sort="Gibson, Jane" uniqKey="Gibson J" first="Jane" last="Gibson">Jane Gibson</name>
<name sortKey="Hammond, Christopher J" sort="Hammond, Christopher J" uniqKey="Hammond C" first="Christopher J" last="Hammond">Christopher J. Hammond</name>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name>
<name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name>
<name sortKey="Lotery, Andrew J" sort="Lotery, Andrew J" uniqKey="Lotery A" first="Andrew J" last="Lotery">Andrew J. Lotery</name>
<name sortKey="Macleod, Alex" sort="Macleod, Alex" uniqKey="Macleod A" first="Alex" last="Macleod">Alex Macleod</name>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D" last="Spector">Timothy D. Spector</name>
<name sortKey="Viswanathan, Ananth C" sort="Viswanathan, Ananth C" uniqKey="Viswanathan A" first="Ananth C" last="Viswanathan">Ananth C. Viswanathan</name>
<name sortKey="Willoughby, Colin E" sort="Willoughby, Colin E" uniqKey="Willoughby C" first="Colin E" last="Willoughby">Colin E. Willoughby</name>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name>
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